State Street® SPDR® MSCI World Health Care UCITS ETF

ISIN IE00BYTRRB94 · SPFS EU

The State Street® SPDR® MSCI World Health Care UCITS ETF is an exchange-traded index fund (ETF) from SPDR that tracks the MSCI World Health Care index physically. With a total expense ratio (TER) of 0.30 % per year it is in the mid cost range for its category. Income is automatically reinvested (accumulating); it trades as a Europe-domiciled UCITS fund. The fund spreads across 110 individual holdings – the largest currently Eli Lilly and Company at 10.96 %. The full composition plus the sector and country breakdown are shown below.

Key facts

Data note 1

Tax (Germany)

Equity ETF: 30 % partial exemption (Teilfreistellung). Accumulating → Vorabpauschale advance tax applies. Details.

The 100 largest holdings

of 110 in total · as of 2026-09-16

Top holdings

#	Stock	Ticker	Weight
1	Eli Lilly and Company	LLY	10.96 %
2	Johnson & Johnson	JNJ	7.74 %
3	AbbVie Inc.	ABBV	5.58 %
4	Merck & Co. Inc.	MRK	4.31 %
5	UnitedHealth Group Incorporated	UNH	4.10 %
6	Novartis AG	NOVN	3.07 %
7	Astrazeneca plc	AZN	2.97 %
8	Thermo Fisher Scientific Inc.	TMO	2.91 %
9	Amgen Inc.	AMGN	2.44 %
10	Gilead Sciences Inc.	GILD	2.20 %
11	Abbott Laboratories	ABT	2.15 %
12	Pfizer Inc.	PFE	1.88 %
13	Novo Nordisk A/S Class B	NOVO B	1.63 %
14	Intuitive Surgical Inc.	ISRG	1.63 %
15	Danaher Corporation	DHR	1.60 %
16	Vertex Pharmaceuticals Incorporated	VRTX	1.57 %
17	Bristol-Myers Squibb Company	BMY	1.56 %
18	Medtronic Plc	MDT	1.43 %
19	CVS Health Corporation	CVS	1.41 %
20	McKesson Corporation	MCK	1.25 %
21	Glaxosmithkline	GSK	1.22 %
22	Stryker Corporation	SYK	1.18 %
23	Sanofi SA	SAN	1.13 %
24	Elevance Health Inc.	ELV	1.08 %
25	Regeneron Pharmaceuticals Inc.	REGN	0.96 %
26	Cigna Group	CI	0.89 %
27	HCA Healthcare Inc	HCA	0.81 %
28	Boston Scientific Corporation	BSX	0.79 %
29	argenx SE	ARGX	0.74 %
30	Takeda Pharmaceutical Co. Ltd.	4502	0.72 %
31	CSL Limited	CSL	0.72 %
32	Cencora Inc.	COR	0.71 %
33	Bayer AG	BAYN	0.67 %
34	Cardinal Health Inc.	CAH	0.66 %
35	Edwards Lifesciences Corporation	EW	0.61 %
36	Becton Dickinson and Company	BDX	0.61 %
37	Hoya Corp.	7741	0.58 %
38	Essilorluxottica SA	EL	0.58 %
39	Natera Inc.	NTRA	0.56 %
40	Lonza Group AG	LONN	0.56 %
41	Humana Inc.	HUM	0.55 %
42	IQVIA Holdings Inc	IQV	0.54 %
43	Teva Pharmaceutical Industries Limited	TEVA	0.54 %
44	Agilent Technologies Inc.	A	0.53 %
45	Waters Corporation	WAT	0.50 %
46	Haleon plc	HLN	0.49 %
47	IDEXX Laboratories Inc.	IDXX	0.49 %
48	Veeva Systems Inc. Class A	VEEV	0.46 %
49	Galderma Group N AG	GALD	0.42 %
50	Illumina Inc.	ILMN	0.41 %
51	DexCom Inc.	DXCM	0.40 %
52	Sandoz Group Ltd	SDZ	0.40 %
53	Alcon AG	ALC	0.40 %
54	Revolution Medicines Inc.	RVMD	0.40 %
55	ResMed Inc.	RMD	0.40 %
56	Centene Corporation	CNC	0.39 %
57	Biogen Inc.	BIIB	0.39 %
58	Alnylam Pharmaceuticals Inc	ALNY	0.38 %
59	Daiichi Sankyo Company Limited	4568	0.37 %
60	Zoetis Inc. Class A	ZTS	0.37 %
61	Otsuka Corp.	4768	0.35 %
62	GE Healthcare Technologies Inc.	GEHC	0.35 %
63	UCB S.A.	UCB	0.35 %
64	Chugai Pharmaceutical Co. Ltd.	4519	0.34 %
65	Mettler-Toledo International Inc.	MTD	0.33 %
66	Quest Diagnostics Incorporated	DGX	0.33 %
67	Labcorp Holdings Inc.	LH	0.32 %
68	Insmed Incorporated	INSM	0.32 %
69	West Pharmaceutical Services Inc.	WST	0.31 %
70	Astellas Pharma Inc.	4503	0.31 %
71	Royalty Pharma Plc Class A	RPRX	0.29 %
72	Fresenius SE & Co. KGaA	FRE	0.27 %
73	Incyte Corporation	INCY	0.25 %
74	Roivant Sciences Ltd.	ROIV	0.25 %
75	Genmab A/S	GMAB	0.25 %
76	STERIS plc	STE	0.25 %
77	Koninklijke Philips N.V.	PHIA	0.24 %
78	Merck KGaA	MRK	0.23 %
79	United Therapeutics Corporation	UTHR	0.23 %
80	Terumo Corporation	4543	0.23 %
81	Zimmer Biomet Holdings Inc.	ZBH	0.22 %
82	Fisher & Paykel Healthcare Corporation Limited	FPH	0.18 %
83	Siemens Healthineers AG	SHL	0.18 %
84	Neurocrine Biosciences Inc.	NBIX	0.17 %
85	Sonova Holding AG	SOON	0.17 %
86	Shionogi & Co. Ltd.	4507	0.16 %
87	Olympus Corp.	7733	0.16 %
88	Roche Holding Ltd	RO	0.16 %
89	Straumann Holding AG	STMN	0.16 %
90	Medline Inc. Class A	MDLN	0.15 %
91	Cooper Companies Inc.	COO	0.13 %
92	Smith and Nephew plc	SN.	0.13 %
93	Orion Oyj Class B	ORNBV	0.13 %
94	Eurofins Scientific SE	ERF	0.11 %
95	Sigma Healthcare Ltd	SIG	0.11 %
96	Qiagen NV	QIA	0.11 %
97	Fresenius Medical Care AG	FME	0.11 %
98	Eisai Co. Ltd.	4523	0.10 %
99	Coloplast A/S Class B	COLO B	0.10 %
100	Swedish Orphan Biovitrum AB	SOBI	0.10 %

Data note 2

NAV history

Net asset value per share in USD, set once per trading day. It is not an exchange price. Distributions are not added back, so for distributing funds the value drops by the amount paid out on the distribution date.

Data note 3

Performance

Calculated from the fund's NAV history.

Data note 4

Published fund performance

Periods of one year and longer are annualized, as of 2026-08-31.

Data note 5

Compared with other funds

How much this fund overlaps with others — the figure is the share of capital financing the same companies in both.

• SPFS vs XMEU10.8 %
• SPFS vs XIEE10.8 %
• SPFS vs 2B7K10.2 %
• SPFS vs XSX610 %
• SPFS vs XSX710 %

Data note 6