State Street® SPDR® MSCI World Health Care UCITS ETF

ISIN IE00BYTRRB94 · SPFS EU

The State Street® SPDR® MSCI World Health Care UCITS ETF is an exchange-traded index fund (ETF) from SPDR that tracks the MSCI World Health Care index physically. With a total expense ratio (TER) of 0.30% per year it is in the mid cost range for its category. Income is automatically reinvested (accumulating); it trades as a Europe-domiciled UCITS fund. The fund spreads across 110 individual holdings – the largest currently Eli Lilly at 12.41%. The full composition plus the sector and country breakdown are shown below; it is one of 104 ETFs we cover.

The ten largest holdings make up 49.3% of the fund, out of 110 in total. The largest sector is Health Care at 100.0% (as of Oct 30, 2026).

Alysly Data Analysis: SPFS

The 100 Largest Holdings

of 110 in total · as of Oct 30, 2026

Top holdings

#	Stock	Ticker	Weight
1	Eli Lilly	LLY	12.41%
2	Johnson & Johnson	JNJ	7.20%
3	AbbVie Inc.	ABBV	5.70%
4	UnitedHealth Group Incorporated	UNH	4.04%
5	Merck & Co. Inc.	MRK	4.04%
6	Roche Holding Ltd	RO	3.93%
7	Novartis AG	NOVN	3.26%
8	Astrazeneca plc	AZN	3.09%
9	Thermo Fisher Scientific Inc.	TMO	2.84%
10	Amgen Inc.	AMGN	2.75%
11	Gilead Sciences Inc.	GILD	2.33%
12	Abbott Laboratories	ABT	2.03%
13	Pfizer Inc.	PFE	1.90%
14	Intuitive Surgical Inc.	ISRG	1.67%
15	Danaher Corporation	DHR	1.62%
16	Vertex Pharmaceuticals Incorporated	VRTX	1.56%
17	Novo Nordisk A/S Class B		1.40%
18	Bristol-Myers Squibb Company	BMY	1.40%
19	Medtronic Plc	MDT	1.36%
20	McKesson Corporation	MCK	1.28%
21	CVS Health Corporation	CVS	1.26%
22	Stryker Corporation	SYK	1.10%
23	Glaxosmithkline	GSK	1.10%
24	Sanofi SA	SAN	1.07%
25	Regeneron Pharmaceuticals Inc.	REGN	1.05%
26	Elevance Health Inc.	ELV	1.00%
27	Cigna Group	CI	0.86%
28	HCA Healthcare Inc	HCA	0.81%
29	CSL Limited	CSL	0.74%
30	Takeda Pharmaceutical Co. Ltd.	4502	0.74%
31	Boston Scientific Corporation	BSX	0.68%
32	Cencora Inc.	COR	0.67%
33	Essilorluxottica SA	EL	0.65%
34	Cardinal Health Inc.	CAH	0.64%
35	argenx SE	ARGX	0.62%
36	Natera Inc.	NTRA	0.62%
37	Hoya Corp.	7741	0.61%
38	Lonza Group AG	LONN	0.61%
39	Bayer AG	BAYN	0.61%
40	Becton Dickinson and Company		0.60%
41	Edwards Lifesciences Corporation	EW	0.58%
42	Agilent Technologies Inc.	A	0.55%
43	Humana Inc.	HUM	0.54%
44	Teva Pharmaceutical Industries Limited	TEVA	0.54%
45	Veeva Systems Inc. Class A	VEEV	0.50%
46	Waters Corporation	WAT	0.50%
47	IQVIA Holdings Inc	IQV	0.49%
48	IDEXX Laboratories Inc.	IDXX	0.48%
49	Galderma Group N AG	GALD	0.47%
50	Sandoz Group Ltd	SDZ	0.46%
51	Haleon plc	HLN	0.42%
52	UCB S.A.	UCB	0.42%
53	Biogen Inc.	BIIB	0.41%
54	Alcon AG	ALC	0.39%
55	Illumina Inc.	ILMN	0.39%
56	Genmab A/S	GMAB	0.39%
57	GE Healthcare Technologies Inc.	GEHC	0.38%
58	Centene Corporation	CNC	0.37%
59	Zoetis Inc. Class A	ZTS	0.36%
60	ResMed Inc.	RMD	0.36%
61	Mettler-Toledo International Inc.		0.36%
62	Revolution Medicines Inc.	RVMD	0.35%
63	Otsuka Corp.	4768	0.35%
64	DexCom Inc.	DXCM	0.35%
65	West Pharmaceutical Services Inc.	WST	0.33%
66	Labcorp Holdings Inc.	LH	0.32%
67	Chugai Pharmaceutical Co. Ltd.	4519	0.32%
68	Daiichi Sankyo Company Limited	4568	0.32%
69	Astellas Pharma Inc.	4503	0.31%
70	Quest Diagnostics Incorporated	DGX	0.31%
71	Royalty Pharma Plc Class A	RPRX	0.30%
72	Insmed Incorporated	INSM	0.26%
73	United Therapeutics Corporation	UTHR	0.25%
74	Fresenius SE & Co. KGaA	FRE	0.25%
75	Alnylam Pharmaceuticals Inc	ALNY	0.24%
76	STERIS plc	STE	0.24%
77	Koninklijke Philips N.V.	PHIA	0.24%
78	Merck KGaA	MRK	0.24%
79	Incyte Corporation	INCY	0.22%
80	Terumo Corporation	4543	0.22%
81	Roivant Sciences Ltd.	ROIV	0.21%
82	Zimmer Biomet Holdings Inc.	ZBH	0.20%
83	Sonova Holding AG	SOON	0.18%
84	Siemens Healthineers AG	SHL	0.17%
85	Fisher & Paykel Healthcare Corporation Limited	FPH	0.17%
86	Shionogi & Co. Ltd.	4507	0.15%
87	Neurocrine Biosciences Inc.	NBIX	0.15%
88	Straumann Holding AG	STMN	0.14%
89	Orion Oyj Class B	ORNBV	0.14%
90	Olympus Corp.	7733	0.13%
91	Medline Inc. Class A	MDLN	0.13%
92	Cooper Companies Inc.		0.13%
93	Smith and Nephew plc	SN.	0.12%
94	Eurofins Scientific SE	ERF	0.12%
95	Qiagen N.V.	QIA	0.12%
96	Sigma Healthcare Ltd	SIG	0.11%
97	Eisai Co. Ltd.	4523	0.10%
98	Coloplast A/S Class B	COLO B	0.10%
99	Swedish Orphan Biovitrum AB	SOBI	0.10%
100	Fresenius Medical Care AG	FME	0.09%

Holdings lists from our database since Sep 30, 2026, 2 reporting dates.

Data note 1

Changes in Holdings

This compares the holdings list of Sep 30, 2026 with that of Oct 30, 2026: 0 names were added and 0 dropped out. Weights also shift without any buying or selling, because the prices of the holdings move differently.

Data note 2

Compared With Other Funds

How much this fund overlaps with others — the figure is the share of capital financing the same companies in both.

• SPFS vs XMEU14.8%
• SPFS vs XIEE14.8%
• SPFS vs XSX613.7%
• SPFS vs XSX713.7%
• SPFS vs 2B7K12.4%

Data note 3

Data and Charts: SPFS

Effective means the number of equally weighted holdings that would produce the same spread as this fund's 110 counted positions.

Data note 4

Key Facts

Data note 5

NAV History

The chart shows net asset value per share and is set to the current year by default. The NAV is up 15.5% year to date and up 23.8% over twelve months. The last recorded close on October 30, 2026, was at 100% of the 52-week range.

Net asset value per share in USD, set once per trading day. It is not an exchange price. Distributions are not added back, so for distributing funds the value drops by the amount paid out on the distribution date.

Net asset values from our database since Apr 29, 2016, 2,689 daily values.

Data note 6

Performance

Calculated from the fund's NAV history.

Data note 7

Published Fund Performance

Periods of one year or longer are annualized, as of Sep 30, 2026.

Data note 8

Fundamental Analysis: SPFS

Tax (Germany)

Equity ETF: 30% partial exemption (Teilfreistellung). Accumulating → Vorabpauschale advance tax applies. Details.