State Street® SPDR® MSCI World Health Care UCITS ETF

ISIN IE00BYTRRB94 · SPFS EU

The State Street® SPDR® MSCI World Health Care UCITS ETF is an exchange-traded index fund (ETF) from SPDR that tracks the MSCI-WORLD-HEALTH-CARE index physically. With a total expense ratio (TER) of 0.30 % per year it is in the mid cost range for its category. Income is automatically reinvested (accumulating); it trades as a Europe-domiciled UCITS fund. The fund spreads across 110 individual holdings – the largest currently Eli Lilly and Company at 10.89 %. That means a single savings-plan building block gives you broad, diversified exposure to an entire market segment – the full composition plus sector and country breakdown are shown below.

Key facts

Data note 1

Tax (Germany)

Equity ETF: 30 % partial exemption (Teilfreistellung). Accumulating → Vorabpauschale advance tax applies. Details.

The 100 largest holdings

of 110 in total · as of 2026-09-11

Top holdings

#	Stock	Ticker	Weight
1	Eli Lilly and Company	LLY	10.89 %
2	Johnson & Johnson	JNJ	7.79 %
3	AbbVie Inc.	ABBV	5.54 %
4	Merck & Co. Inc.	MRK	4.33 %
5	UnitedHealth Group Incorporated	UNH	4.20 %
6	Novartis AG	NOVN	3.07 %
7	Astrazeneca plc	AZN	2.92 %
8	Thermo Fisher Scientific Inc.	TMO	2.77 %
9	Amgen Inc.	AMGN	2.48 %
10	Gilead Sciences Inc.	GILD	2.17 %
11	Abbott Laboratories	ABT	2.17 %
12	Pfizer Inc.	PFE	1.92 %
13	Novo Nordisk A/S Class B	NOVO B	1.69 %
14	Vertex Pharmaceuticals Incorporated	VRTX	1.60 %
15	Intuitive Surgical Inc.	ISRG	1.59 %
16	Bristol-Myers Squibb Company	BMY	1.58 %
17	Danaher Corporation	DHR	1.55 %
18	CVS Health Corporation	CVS	1.47 %
19	Medtronic Plc	MDT	1.42 %
20	McKesson Corporation	MCK	1.26 %
21	Glaxosmithkline	GSK	1.18 %
22	Stryker Corporation	SYK	1.16 %
23	Banco Santander S.A.	SAN	1.14 %
24	Elevance Health Inc.	ELV	1.11 %
25	Regeneron Pharmaceuticals Inc.	REGN	0.98 %
26	Cigna Group	CI	0.90 %
27	HCA Healthcare Inc	HCA	0.82 %
28	Boston Scientific Corporation	BSX	0.78 %
29	argenx SE	ARGX	0.75 %
30	Cencora Inc.	COR	0.72 %
31	Takeda Pharmaceutical Co. Ltd.	4502	0.72 %
32	CSL Limited	CSL	0.70 %
33	Cardinal Health Inc.	CAH	0.67 %
34	Bayer AG	BAYN	0.67 %
35	Hoya Corp.	7741	0.61 %
36	Becton Dickinson and Company	BDX	0.60 %
37	Essilorluxottica SA	EL	0.60 %
38	Humana Inc.	HUM	0.60 %
39	Edwards Lifesciences Corporation	EW	0.59 %
40	Lonza Group AG	LONN	0.56 %
41	Natera Inc.	NTRA	0.54 %
42	IQVIA Holdings Inc	IQV	0.54 %
43	Teva Pharmaceutical Industries Limited Sponsored ADR	TEVA	0.53 %
44	Agilent Technologies Inc.	A	0.51 %
45	Haleon plc	HLN	0.49 %
46	Waters Corporation	WAT	0.49 %
47	IDEXX Laboratories Inc.	IDXX	0.48 %
48	Veeva Systems Inc. Class A	VEEV	0.47 %
49	Galderma Group N AG	GALD	0.43 %
50	Revolution Medicines Inc.	RVMD	0.42 %
51	Sandoz Group Ltd	SDZ	0.41 %
52	Alnylam Pharmaceuticals Inc	ALNY	0.40 %
53	Centene Corporation	CNC	0.40 %
54	Alcon AG	ALC	0.40 %
55	Biogen Inc.	BIIB	0.39 %
56	DexCom Inc.	DXCM	0.39 %
57	ResMed Inc.	RMD	0.38 %
58	Illumina Inc.	ILMN	0.38 %
59	Otsuka Corp.	4768	0.38 %
60	Zoetis Inc. Class A	ZTS	0.37 %
61	Daiichi Sankyo Company Limited	4568	0.37 %
62	GE Healthcare Technologies Inc.	GEHC	0.35 %
63	UCB S.A.	UCB	0.35 %
64	Chugai Pharmaceutical Co. Ltd.	4519	0.35 %
65	Insmed Incorporated	INSM	0.34 %
66	Quest Diagnostics Incorporated	DGX	0.32 %
67	Mettler-Toledo International Inc.	MTD	0.31 %
68	Labcorp Holdings Inc.	LH	0.31 %
69	Astellas Pharma Inc.	4503	0.31 %
70	West Pharmaceutical Services Inc.	WST	0.30 %
71	Royalty Pharma Plc Class A	RPRX	0.29 %
72	Fresenius SE & Co. KGaA	FRE	0.27 %
73	Roivant Sciences Ltd.	ROIV	0.26 %
74	STERIS plc	STE	0.25 %
75	Incyte Corporation	INCY	0.25 %
76	Koninklijke Philips N.V.	PHIA	0.24 %
77	Genmab A/S	GMAB	0.24 %
78	Merck & Co. Inc.	MRK	0.24 %
79	United Therapeutics Corporation	UTHR	0.23 %
80	Terumo Corporation	4543	0.23 %
81	Zimmer Biomet Holdings Inc.	ZBH	0.22 %
82	Neurocrine Biosciences Inc.	NBIX	0.18 %
83	Siemens Healthineers AG	SHL	0.18 %
84	Fisher & Paykel Healthcare Corporation Limited	FPH	0.18 %
85	Olympus Corp.	7733	0.17 %
86	Sonova Holding AG	SOON	0.16 %
87	Shionogi & Co. Ltd.	4507	0.16 %
88	Straumann Holding AG	STMN	0.16 %
89	Roche Holding Ltd	RO	0.15 %
90	Medline Inc. Class A	MDLN	0.15 %
91	Cooper Companies Inc.	COO	0.13 %
92	Smith and Nephew plc	SN.	0.13 %
93	Orion Oyj Class B	ORNBV	0.12 %
94	Sigma Healthcare Ltd	SIG	0.12 %
95	Qiagen NV	QIA	0.11 %
96	Eurofins Scientific SE	ERF	0.11 %
97	Eisai Co. Ltd.	4523	0.10 %
98	Fresenius Medical Care AG	FME	0.10 %
99	Swedish Orphan Biovitrum AB	SOBI	0.10 %
100	Coloplast A/S Class B	COLO B	0.10 %

Data note 2

NAV history

Net asset value per share in USD, set once per trading day. It is not an exchange price. Distributions are not added back, so for distributing funds the value drops by the amount paid out on the distribution date.

Data note 3

Performance

Calculated from the fund's NAV history.

Data note 4

Performance as reported by the issuer

Periods of one year and longer are annualized, as of 2026-08-31.

Data note 5

Compared with other funds

How much this fund overlaps with others — the figure is the share of capital financing the same companies in both.

• SPFS vs XMEU10.5 %
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